Careers at Children's Cancer Institute
Clinical Curation Scientist (Personalised Medicine)

Location:
Randwick - Sydney, Australia  
Employment Type:
Full-Time Fixed Term  
Department:
Personalised Medicine (PM)
Supporting Documentation:

  • Innovative, collaborative and positive team-orientated environment
  • Modern, world-class facilities
  • Convenient Randwick location, close to transport

 

Children’s Cancer Institute is the only medical research institute in Australia wholly dedicated to curing childhood cancer and one of the leading medical childhood cancer research institutes worldwide. Our vision is to save the lives of all children with cancer and improve their long-term health, we don’t just hope to do it, we will do it; and we’re looking for the brightest minds to help us get there. Children’s Cancer Institute provides the best possible environment for our staff thrive with state-of-the-art facilities at the Lowy Cancer Research Centre, UNSW Australia – one of the leading cancer research centres in the world. 

We are leading the national Zero Childhood Cancer personalised medicine program for children with the most aggressive cancers, in partnership with the Sydney Children’s Hospitals Network. Zero Childhood Cancer is the most exciting childhood cancer research initiative ever undertaken in Australia and is a world-leading initiative www.zerochildhoodcancer.org.au. The Zero Childhood Cancer Program generates a large amount of complex multi ‘omics data (genomic, transcriptomic, epigenetic, in vitro and in vivo drug response modelling data) that requires skilled interpretation, curation, and classification.

We currently have an opportunity for a Clinical Curation Scientist to join our team on a Full-time fixed term basis initially, with a strong potential to extend. This position will report to the Program Leader and be positioned within the multidisciplinary ‘Omics team, and will suit a friendly and outgoing personality who can work with people openly across all components of an organisation. Critical to the role is a clinically orientated and organised approach with an eye for detail and experience in analysis, research, and interpretation of genomic and other complex laboratory data outputs, leading to the delivery of a comprehensive and meaningful clinical research report to a multidisciplinary tumour board (MTB) and treating clinicians. 


Responsibilities will include, but are not limited to:

  • Assessment of pathogenicity and targetable genetic aberrations including variant, fusion gene, and copy number analysis and interpretation, both somatic and germline.
  • Provide support, training, and knowledge transfer to research staff involved in the annotation and curation process.
  • Conduct literature and existing databases research to match drugs to potential targets for an individual’s cancer.
  • Streamline the process of variant assessment and curation.
  • Develop, maintain, and follow standard protocols for assigning a classification per pathogenicity and actionable target/drug classification tiers as determined by existing standards and guidelines, and the ‘Omics team.
  • Maintain scientifically accurate content within the laboratory knowledgebase for accurate clinical reporting.

Qualifications, experience and skills required:

  • The equivalent of an MHGSA / FHGSA / RCPA FFSc Genetic Pathology / master’s or post graduate degree in molecular genetics, human medical genetics, or molecular / genetic pathology with a minimum of 2 years variant classification experience
  • Demonstrate thoroughness, strong analytical skills, and an ability to understand, evaluate, and interpret published literature and clinical data to provide accurate, thorough, and thoughtful clinical interpretation of research results in a critical manner on a daily basis is required.
  • Demonstrated ability in providing accurate and timely genomic variant assessment from genomic data (both germline and somatic) derived from human clinical samples to provide accurate clinical interpretation of results in addition to training in sequencing technologies and familiarity with basic concepts of bioinformatics pipelines is required.
  • Extensive experience in data mining and organisation of data with a strong knowledge of oncology genetics somatic and germline knowledgebases is preferred.
  • Demonstrated thorough and ongoing knowledge of current theories and principals of human medical genetics, cancer genetics, genetic cancer predisposition, and targeted therapies is preferred.
  • Experience working in a clinical environment and frequent interaction with clinicians and health professionals is desirable.

 

Children’s Cancer Institute is strongly committed to the growth of their employees, so all team members can fulfil their aspirations. You'll be rewarded with a friendly and professional flexible work environment, comprehensive on-campus facilities, competitive salary, salary packaging options, on-site parking options, access to a leading EAP program and regular social activities. Join a group of dedicated people in a performance-driven environment to achieve success and discover what it's like to look forward to coming to work every day and make a real difference. We're looking for people who share our values of accountability, integrity and camaraderie, teamwork, sharing and excellence, success and satisfaction. 

A detailed job description and additional information about Children's Cancer Institute can be found on our website at: www.childrenscancerinstitute.org.au. We embrace diversity and encourage applications from people from diverse backgrounds and cultures. 

To apply, please click the 'APPLY' link and forward both your resume AND cover letter clearly addressing the qualifications, experience and skills required.  Note: Applications will be reviewed prior to the closing date; which is dependent on the status of the recruitment process.