Careers at Children's Cancer Institute
Research Officer – High throughput drug screening to guide precision medicine

Location:
Randwick - Sydney, Australia  
Employment Type:
Full-Time Fixed Term  
Department:
Personalised Medicine (PM)
Supporting Documentation:

  • Innovative, collaborative and positive team-orientated environment
  • Modern, world-class facilities
  • Convenient Randwick location, close to transport

 

The Zero Childhood Cancer national personalised medicine Program (ZERO), a joint initiative of Children’s Cancer Institute and Kids Cancer Centre, Sydney Children’s Hospital, Randwick, was established to identify improved treatment options for paediatric cancer patients. Strategies to identify personalised treatment options include full molecular profiling of tumour biopsies, high-throughput in vitro drug testing on patient-derived model systems and in vivo drug validation in patient-derived xenograft models. To elevate the in vitro drug testing pipeline to the highest level of clinical translation, you are a highly enthusiastic and motivated Research Officer with a great interest in improving treatment options for children with cancer using high-content data.

 

The Research Officer will support the Zero Preclinical Drug Testing Core Senior Scientist with the design and implementation of methods and (laboratory) technologies to improve the in vitro drug testing pipeline, data analysis and interpretation and data sharing with clinicians and other team members involved, and will contribute to the design and performance of strategic research projects to enhance the testing platform and accelerate improved treatment options for children with cancer. This position requires excellent teamwork and communication skills, adaptability, meticulous attention to detail, and close adherence to deadlines so that test results can be provided in a timely manner.


Responsibilities will include, but are not limited to:

  • Update and maintain a drug information database containing all relevant information for in vitro testing (i.e. compatibility with solvents, active metabolites) and clinical translation of drug testing results (i.e. targets, blood-brain barrier permeability, maximum tolerated plasma concentrations, development phase, availability of paediatric doses)
  • Have knowledge on and be able to perform all steps involved in high-throughput screening of small molecule libraries for in vitro drug efficacy testing on patient-derived cells from haematologic and solid tumours
  • Support with data analysis and interpretation
  • Support with organising and leading drug curation meetings to share and discuss drug screening results with treating clinicians and other team members involved in the Zero Childhood Cancer national precision medicine trial
  • Support with the design of drug combination screens for implementation in the preclinical drug testing pipeline
  • Design and implement other methods or (laboratory) technologies to improve the in vitro drug testing pipeline
  • Design and carry out research projects with high strategic priority as agreed
  • Contribute to and develop relevant manuscripts
  • Guide and support the Research Assistants/Technicians working on in vitro drug testing as part of the national precision medicine trial
  • Supervise undergraduate and/or higher degree students

 

Qualifications, experience and skills required:

  • 5+ years laboratory experience
  • Experience with cancer cell biology
  • Experience with in vitro drug testing including drug combination testing is highly desirable
  • Experience with primary cell cultures is highly desirable
  • Experience with supervising students and/or Research Assistants/Technicians is highly desirable
  • Experience with writing manuscripts
  • Advanced computer skills
  • Experience with PC2 and WHS standards and behaviour highly desirable
  • Commitment to conducting experiments involving humans, animals & GMOs under strict ethical and regulatory guidelines

Children’s Cancer Institute is strongly committed to the growth of their employees, so all team members can fulfil their aspirations. You'll be rewarded with a friendly and professional flexible work environment, comprehensive on-campus facilities, competitive salary, salary packaging options, on-site parking options, access to a leading EAP program and regular social activities. Join a group of dedicated people in a performance-driven environment to achieve success and discover what it's like to look forward to coming to work every day and make a real difference. We're looking for people who share our values of accountability, integrity and camaraderie, teamwork, sharing and excellence, success and satisfaction. 

A detailed job description and additional information about Children's Cancer Institute can be found on our website at: www.childrenscancerinstitute.org.au. We embrace diversity and encourage applications from people from diverse backgrounds and cultures. 

To apply, please click the 'APPLY' link and forward both your resume AND cover letter clearly addressing the qualifications, experience and skills required.  Note: Applications will be reviewed prior to the closing date; which is dependent on the status of the recruitment process.